Description

Melanotan II

Melanotan II is a selective growth hormone secretagogue (GHS) that mimics the effects of ghrelin, the body’s natural “growth hormone–releasing” peptide.  It stimulates the pituitary gland to release endogenous GH without significantly affecting cortisol or prolactin levels, making it one of the cleanest and most controllable GHRPs available.

RESEARCH

Melanotan II is a laboratory-engineered peptide designed to mimic and enhance the biological activity of α-MSH, a key component of the melanocortin signaling pathway. It has been extensively studied for its ability to stimulate melanin production, influence appetite and energy balance, and modulate sexual arousal pathways via melanocortin receptor activation.

Melanotan II supports research into photoprotection, melanin synthesis, and neuroendocrine modulation, making it one of the most frequently studied peptides in pigmentation and melanocortin biology.

CHEMICAL INFORMATION

• Molecular Formula: C50H69N15O9
  Molecular Weight:2 g/mol
  Sequence: Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (cyclic heptapeptide)

RESEARCH APPLICATIONS

• Stimulate Melanin Production. Investigate MT-2’s ability to activate melanocortin-1 receptors and enhance melanin synthesis for pigmentation biology studies.
• Support Photoprotection Research. Explore its role in increasing eumelanin levels, supporting research on UV-response and skin-cell photoprotection.
• Examine Appetite and Energy Regulation. Study its interactions with MC3R and MC4R receptors involved in satiety, metabolic rate, and hypothalamic signaling.
• Evaluate Sexual Function Pathways. Research its potential influence on neuroendocrine signaling associated with libido and arousal.
• Analyze Anti-Inflammatory and Immunomodulatory Actions. Investigate its effects on melanocortin-mediated inflammatory pathways in cellular and molecular studies.

STORAGE AND HANDLING

• Store lyophilized powder at -20°C.
• Once reconstituted, store at 2-8°C and use promptly.
• Maintain aseptic techniques during handling to ensure sterility.

PRODUCT SPECIFICATION

• Purity: ≥99% (HPLC Certified)
• Appearance: Lyophilized off-white powder
• Solubility: Soluble in bacteriostatic water

COMPLIANCE NOTICE

Melanotan II is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA and is not to be used for therapeutic, diagnostic, or clinical purposes. Any misuse of this product may violate applicable laws and regulations. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

BENEFITS BEING RESEARCHED

• Melanocortin receptors (MC1R → pigmentation; MC3R/MC4R → energy balance)
• Melanin synthesis studies and UV-response modeling
• Neuroendocrine pathways connected to appetite, metabolism, and libido
• Antioxidant and photoprotective signaling effects in experimental systems
• Stable, highly potent analog of endogenous α-MSH for controlled receptor studies

MECHANISM OF ACTION (Simplified)

1. Activates MC1R receptors → increases melanin production and pigmentation response
2. Stimulates MC3R/MC4R pathways → modulates appetite and energy expenditure signaling
3. Engages CNS melanocortin receptors → affects neuroendocrine outputs related to arousal
4. Enhances cellular stress response → supports antioxidant and photoprotective processes
5. Stabilized cyclic structure → increases receptor affinity and resistance to enzymatic breakdown

FORM / NOTES

• Lyophilized vial for reconstitution
• Stable structure suitable for receptor-binding and signaling pathway assays

LEGAL DISCLAIMER

This product is sold strictly for laboratory research use only.

By purchasing this product, the buyer represents and warrants that:

• The material will be used solely for in-vitro research purposes
• The buyer is qualified to handle laboratory reagents
• The product will not be used for human or animal consumption, injection, or application

Revyon Technologies assumes no liability for misuse or improper handling.

IMPORTANT NOTICE

Any use outside of stated research purposes is strictly prohibited.