Description

PT-141

PT-141 (Bremelanotide) is a synthetic melanocortin receptor agonist derived from the α-melanocyte-stimulating hormone (α-MSH) analog Melanotan II.

Unlike vascular-targeted agents, PT-141 functions primarily through central nervous system pathways, directly activating melanocortin receptors within the hypothalamus that regulate sexual arousal and motivation.

PT-141 is widely studied for its effects on libido enhancement, erectile response, sexual motivation, and neuroendocrine signaling in both male and female research models.

RESEARCH

PT-141 is a synthetic peptide analog of α-MSH designed to selectively activate melanocortin receptors involved in sexual function and energy regulation.

Research demonstrates that PT-141 primarily acts as an agonist at melanocortin-4 receptors (MC4R) and, to a lesser extent, melanocortin-1 receptors (MC1R). Activation of MC4R in the central nervous system has been associated with increased sexual arousal and motivation in preclinical and clinical research models.

Unlike phosphodiesterase-5 (PDE5) inhibitors that act peripherally on vascular smooth muscle, PT-141 exerts centrally mediated neuroendocrine effects, making it a distinct compound for research focused on CNS-driven sexual response pathways.

CHEMICAL INFORMATION

• Molecular Formula: C₅₀H₆₈N₁₄O₁₀
• Molecular Weight: 1025.2 g/mol
• Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
• CAS Number: 189691-06-3
• Structure: Cyclic heptapeptide melanocortin analog

RESEARCH APPLICATIONS

• Sexual Function & Libido Research. Investigate centrally mediated sexual arousal pathways via MC4R activation.
• Neuroendocrine Signaling Studies. Examine hypothalamic receptor activation and downstream dopamine-related signaling.
• Energy & Appetite Regulation Research. Explore melanocortin receptor influence on metabolic and energy balance pathways.
• Pigmentation & MC1R Studies. Assess melanocyte activation and potential pigmentation signaling mechanisms.
• Inflammatory & Immune Modulation Research. Study melanocortin receptor involvement in anti-inflammatory signaling models.

STORAGE AND HANDLING

• Store lyophilized powder at -20°C.
• Once reconstituted, store at 2-8°C and use promptly.
• Maintain aseptic techniques during handling to ensure sterility.

PRODUCT SPECIFICATION

• Purity: ≥99% (HPLC Certified)
• Appearance: Lyophilized white powder
• Solubility: Soluble in bacteriostatic water

COMPLIANCE NOTICE

PT-141 is FOR RESEARCH USE ONLY. It is not intended for human or veterinary use. This product has not been evaluated by the FDA and is not to be used for therapeutic, diagnostic, or clinical purposes. Any misuse of this product may violate applicable laws and regulations. By purchasing this product, buyer represents and warrants that it will be used only for in vitro research purposes.

BENEFITS BEING RESEARCHED

• Selective melanocortin receptor agonist (MC4R primary target)
• Centrally acting compound influencing sexual arousal pathways
• Distinct from PDE5 inhibitors (non-vascular mechanism)
• Modulates neuroendocrine and dopamine-associated signaling
• Investigated for libido and sexual motivation in both male and female research models
• May exhibit mild MC1R-mediated pigmentation activity

MECHANISM OF ACTION (Simplified)

1. Agonizes melanocortin-4 receptors (MC4R) in the hypothalamus
   → enhances centrally mediated sexual arousal signaling
2. Modulates dopamine-associated neural circuits
   → supports motivation and reward pathway modeling
3. Bypasses nitric oxide–dependent vascular pathways
   → differentiates from PDE5 inhibitor research models
4. Secondary MC1R interaction
   → may influence pigmentation-related signaling
5. Engages neuroendocrine feedback systems
   → relevant for reproductive and hormonal research frameworks

FORM / NOTES

• Lyophilized 10 mg vial for reconstitution
• Cyclic melanocortin analog derived from α-MSH
• Suitable for CNS-mediated arousal and melanocortin receptor research
• Commonly compared to Melanotan II, but optimized for MC4R-driven neuroendocrine signaling

LEGAL DISCLAIMER

This product is sold strictly for laboratory research use only.

By purchasing this product, the buyer represents and warrants that:

• The material will be used solely for in-vitro research purposes
• The buyer is qualified to handle laboratory reagents
• The product will not be used for human or animal consumption, injection, or application

Revyon Technologies assumes no liability for misuse or improper handling.

IMPORTANT NOTICE

Any use outside of stated research purposes is strictly prohibited.